Modular Purification Systems LLC
Selected Publications
We have selected key publications in hemodialysis, hemoperfusion, nano-enhanced dialysis methods,
and the parametric design of polymeric composites.
Hemodialysis
R Tehrani, A Gillespie, J Alderfer – Journal of the American Society of Nephrology (JASN), 2023
Nano-Slurry improved the efficiency in both in-vitro single pass and recirculated hemodialysis models. The addition of nanoscale adsorbents improved the efficiency of dialysis and can be incorporated into a novel hemodialysis machine that can recirculate dialysate, reducing water consumption for both in-center and home hemodialysis.
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Can Oral Potassium Binders be Added to Dialysate to Improve the Efficacy of Hemodialysis?
R Tehrani, A Gillespie, J Alderfer – Journal of the American Society of Nephrology (JASN), 2023
The addition of commercially available K+ binder, sodium zirconium cyclosilicate (ZS-9), effectively lowered potassium using recirculated dialysate while maintaining a minimal concentration gradient throughout the treatment. The addition of K+ binders to dialysate can be incorporated into a novel hemodialysis machine that can recirculate dialysate and offer the management of K+ throughout the treatment.
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Can Oral Phosphate Binders be Added to Dialysate to Improve the Efficacy of Hemodialysis?
R Tehrani, A Gillespie, J Alderfer – Journal of the American Society of Nephrology (JASN), 2023
The addition of Sevelamer Carbonate (SC) effectively lowered phosphate using recirculated dialysate and can be incorporated into a novel hemodialysis machine that can recirculate dialysate, reducing water consumption for both in-center and home hemodialysis. While SC effectively reduced phosphate levels, its addition to the dialysate has been found to influence the dialysate pH. Therefore, careful consideration must be given to pH adjustment when utilizing SC. Maintaining appropriate dialysate pH is crucial for ensuring patient safety and optimizing dialysis outcomes.
MPS LLC
MPS LLC
Hemoperfusion
Microwave-assisted Synthesis of Poly(methacrylic acid) Particles for Blood Purification
Advanced Matereials Interfaces, 2025, 12, 2400316
A new method is introduced for the rapid synthesis of poly(methacrylic acid) (PMAA) macroparticles via microwave irradiation, optimizing the ratio of monomer to crosslinker to finely tailor the particles’ characteristics. In the study, the characteristics of these particles have been analyzed extensively, and their potential efficacy in blood purification applications has been explored.
EngineeringPorosity-Tuned Chitosan Beads: BalancingPorosity, Kinetics,andMechanical Integrity
ACS Omega 2024, 9, 33857−33867
Chitosan, a cationic natural polysaccharidederived fromthe deacetylationof chitin, isknownfor its solubility indilutedacidicsolutions, biodegradability,biocompatibility,andnontoxicity.Thisstudyintroducesthree innovativemethods for preparing various types of porous chitosanbeads: solventextraction, surfactantextraction, andsubstancedecomposition.These methods involvethe integrationandsubsequentextractionordecomposition ofmaterialsduringthesynthesisprocess, eliminatingtheneedforadditional steps.
Nano-Enhanced Dialytic Systems
Nano-Enhanced Dialytic Fluid Purification System: Applications and Computational Fluid Dynamics Modeling of a Nanoadsorbent Slurry
K Atmatzidis, 2024, Temple University
Nano-enhanced Dialytic Fluid Purification:
CFD Modeling of Pb(II) Removal by Manganese Oxide
In our previous work, we demonstrated how a simplified tubular dialytic system can employ a stream of suspended ferrihydrite nanoparticles to remove arsenite from an aqueous solution. This treatment method, known as nanoenhanced dialytic fluid purification, was proposed as a novel alternative method for employing nanoadsorbents in water treatment. It eliminated the need for supporting media and maintained a continuous separation between the treated water and the nanoadsorbent fluid stream via a membrane barrier. The nanoenhanced dialytic system provided continuous, fast contaminant removal until the adsorbent was exhausted. Spent material could then be easily removed and replaced without requiring an additional separation mechanism and without disrupting the solution being treated. In essence, our demonstrated process was an evolution of dialysis used in biomedical applications and aimed to address the challenges of applying nanomaterials in water treatment using conventional method.
ACS Omega 2020, 5, 32697−32705
