We have selected key publications in hemodialysis, hemoperfusion, nano-enhanced dialysis methods,
and the parametric design of polymeric composites.

Hemodialysis (Nano-Enhanced Dialysis)

Improving the Efficacy and Efficiency of Hemodialysis by Adding Nanoscale Activated Carbon (Nano-Slurry) Sorbent to the Dialysate 

R Tehrani, A Gillespie, J Alderfer – Journal of the American Society of Nephrology (JASN), 2023

Nano-Slurry improved the efficiency in both in-vitro single pass and recirculated hemodialysis models. The addition of nanoscale adsorbents improved the efficiency of dialysis and can be incorporated into a novel hemodialysis machine that can recirculate dialysate, reducing water consumption for both in-center and home hemodialysis.

​Can Oral Potassium Binders be Added to Dialysate to Improve the Efficacy of Hemodialysis?

R Tehrani, A Gillespie, J Alderfer – Journal of the American Society of Nephrology (JASN), 2023

The addition of commercially available K+ binder, sodium zirconium cyclosilicate (ZS-9), effectively lowered potassium using recirculated dialysate while maintaining a minimal concentration gradient throughout the treatment. The addition of K+ binders to dialysate can be incorporated into a novel hemodialysis machine that can recirculate dialysate and offer the management of K+ throughout the treatment.

​Can Oral Phosphate Binders be Added to Dialysate to Improve the Efficacy of Hemodialysis?

R Tehrani, A Gillespie, J Alderfer – Journal of the American Society of Nephrology (JASN), 2023

The addition of Sevelamer Carbonate (SC) effectively lowered phosphate using recirculated dialysate and can be incorporated into a novel hemodialysis machine that can recirculate dialysate, reducing water consumption for both in-center and home hemodialysis. While SC effectively reduced phosphate levels, its addition to the dialysate has been found to influence the dialysate pH. Therefore, careful consideration must be given to pH adjustment when utilizing SC. Maintaining appropriate dialysate pH is crucial for ensuring patient safety and optimizing dialysis outcomes.

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